A METAHEURISTIC FOR A TIME-DEPENDENT VEHICLE ROUTING PROBLEM WITH TIME WINDOWS, TWO VEHICLE FLEETS AND SYNCHRONIZATION ON A ROAD NETWORK

A metaheuristic for a time-dependent vehicle routing problem with time windows, two vehicle fleets and synchronization on a road network

In this work, we extend the time-dependent vehicle routing problem with time windows on a road network by considering two types of vehicles, large and small, to serve customers.Motivated from city logistics applications, large vehicles are forbidden from the Leggings downtown area.Accordingly, goods must be transferred from large to small vehicles

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The Benign Clone Causing Aplastic Anaemia

Severe Aplastic Anaemia (SAA) is a rare benign disease but carries a high-mortality rate unless treated in Savers a specialised centre.Overwhelming laboratory and clinical evidence points to an autoimmune pathogenesis; although, the aetiology remains obscure in the majority of cases.The differential diagnosis in older patients is problematical and

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Diagnostic and prognostic value of neutrophil gelatinase associated lipocalin and cancer antigen 15-3 serum levels in benign and malignant breast disease

Purpose: Increased neutrophil gelatinase-associated lipocalin (NGAL) serum levels have been shown in studies for colorectal, gastric, esophageal, liver, thyroid and lung cancer.The aim of this Transmission Coolers study was to demonstrate the differences of NGAL and cancer antigen 15-3 (CA15-3) serum levels between the groups of patients diagnosed

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